Kansas City Chiefs at Buffalo Bills odds, picks and best bets – USA TODAY Sportsbook Wire

The Kansas City Chiefs (4-1) face the Buffalo Bills (4-1) in the first of two Week 6 Monday contests. This game was rescheduled from Thursday night and kickoff will now be at 5 p.m. ET at Bills Stadium. Below, we preview the Chiefs-Bills Week 6 betting odds and lines and make our NFL picks and best bets.

Chiefs at Bills betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 8:20 a.m. ET.

  • Money line: Chiefs -238 (bet $238, win $100) | Bills +195 (bet $100, win $195)
  • Against the spread/ATS: Chiefs -5.5 (-115) | Bills +5.5 (-106)
  • Over/Under: 55.5 (O: -110, U: -110)

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Chiefs at Bills game notes

  • The Chiefs and Bills lead the AFC West and AFC East, respectively. Both teams suffered their first loss of the season last week with the Chiefs losing 40-32 at home to the Las Vegas Raiders. The Bills lost 42-16 Tuesday at the Tennessee Titans.
  • Both teams pass over 60% of the time with the Bills ranked 11th in the NFL