Buffalo Bills at Tennessee Titans odds, picks and best bets – USA TODAY Sportsbook Wire

After being delayed due to a COVID-19 outbreak, the Buffalo Bills (4-0) and Tennessee Titans (3-0) will finally square off Tuesday night at Nissan Stadium in Nashville, with kickoff set for 7 p.m. ET. Here, we analyze the Bills-Titans Week 5 matchup, including the betting odds, spread and lines, and look at the best NFL betting options.

Bills at Titans betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:48 a.m. ET.

  • Money line: Bills -185 (bet $185, win $100) | Titans +150 (bet $100, win $150)
  • Against the spread/ATS: Bills -3.5 (-106) | Titans +3.5 (-115)
  • Over/Under: 51.5 (O: -115, U: -106)

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Bills at Titans game notes

  • The Bills and Titans both rank outside the top 20 in passing yards allowed per game. Tennessee is also 31st in rushing yards allowed per game (166.0).
  • Tennessee is allowing the second-most yards per play on defense.
  • The Bills are 4-6 in their last 10 meetings with the Titans, but the series is split 5-5 ATS.
  • The total is 3-0-1 in the Bills’ four games this season. The Titans are 2-1 against the Over/Under.
  • The Titans have yet to cover the spread this season, going 0-3. Buffalo is 3-1 ATS.

Bills at Titans key injuries